| Short Description : | Rabbit polyclonal anti-D4 dopamine receptor dopamine receptor (355-404 aa) for use in WB, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DRD4 |
| Gene ID: | 1815 |
| Uniprot ID: | DRD4_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human DRD4 at the amino acid range 355-404 |
| Immunogen Region: | 355-404 aa |
| Specificity: | D4DR Polyclonal Antibody detects endogenous levels of D4DR protein. |
| Post Translational Modifications | Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein. Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane. |
| Function | Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells. |
| Protein Name | D(4 Dopamine ReceptorD(2c Dopamine ReceptorDopamine D4 Receptor |
| Database Links | Reactome: R-HSA-390651Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-D(4 Dopamine Receptor antibodyAnti-D(2c Dopamine Receptor antibodyAnti-Dopamine D4 Receptor antibodyAnti-DRD4 antibody |
Information sourced from Uniprot.org
