Anti-DVL1 antibody (510-640) (STJ116411)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DVL1 (510-640) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DVL1 |
| Gene ID | 1855 |
| Uniprot ID | DVL1_HUMAN |
| Immunogen Region | 510-640 |
| Immunogen Sequence | GQGYPYQYPGPPPCFPPAYQ DPGFSYGSGSTGSQQSEGSK SSGSTRSSRRAPGREKERRA AGAGGSGSESDHTAPSGVGS SWRERPAGQLSRGSSPRSQA SATAPGLPPPHPTTKAYTVV GGPPGGPPVRE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 510-640 of human DVL1 (NP_004412.2). |
Additional Info
| Post Translational Modifications | Ubiquitinated.undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. |
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-1Dishevelled-1Dsh Homolog 1 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-201688Reactome: R-HSA-4086400Reactome: R-HSA-4641258Reactome: R-HSA-4641262Reactome: R-HSA-5368598Reactome: R-HSA-5663220Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolCytoplasmic VesicleLocalizes At The Cell Membrane Upon Interaction With Frizzled Family Members |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-1 antibodyAnti-Dishevelled-1 antibodyAnti-Dsh Homolog 1 antibodyAnti-DVL1 antibody |
Information sourced from Uniprot.org