| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Endophilin-A1/SH3GL2 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000. WB: Approx 38kDa band observed in Human Brain (Frontal Cortex) lysates (calculated MW of 40.0kDa according to NP_003017.1). Recommended concentration: 0.3-1µg/ml. IHC: In paraffin embe |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SH3GL2 |
| Gene ID: | 6456 |
| Uniprot ID: | SH3G2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_003017.1 |
| Immunogen Sequence: | SLEFPTGDSTQPN |
| Function | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. |
| Protein Name | Endophilin-A1 Een-B1 Endophilin-1 Sh3 Domain Protein 2a Sh3 Domain-Containing Grb2-Like Protein 2 |
| Database Links | Reactome: R-HSA-177504 Reactome: R-HSA-182971 Reactome: R-HSA-2132295 Reactome: R-HSA-432720 Reactome: R-HSA-432722 Reactome: R-HSA-437239 Reactome: R-HSA-6807004 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8875360 |
| Cellular Localisation | Cytoplasm Membrane Peripheral Membrane Protein Early Endosome Presynapse |
| Alternative Antibody Names | Anti-Endophilin-A1 antibody Anti-Een-B1 antibody Anti-Endophilin-1 antibody Anti-Sh3 Domain Protein 2a antibody Anti-Sh3 Domain-Containing Grb2-Like Protein 2 antibody Anti-SH3GL2 antibody Anti-CNSA2 antibody Anti-SH3D2A antibody |
Information sourced from Uniprot.org