| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FANCC |
| Gene ID: | 2176 |
| Uniprot ID: | FANCC_HUMAN |
| Immunogen Region: | 340-558 |
| Immunogen Sequence: | YFPYTSPSLAMVLLQDPQDI PRGHWLQTLKHISELLREAV EDQTHGSCGGPFESWFLFIH FGGWAEMVAEQLLMSAAEPP TALLWLLAFYYGPRDGRQQR AQTMVQVKAVLGHLLAMSRS SSLSAQDLQTVAGQGTDTDL RAPAQQLIRHLLLNFLLWAP GGHTIAWDVITLMAHTAEIT HEIIGFLDQTLYRWNRLGIE SPRSEKLARELLKELRTQV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-558 of human FANCC (NP_000127.2). |
| Tissue Specificity | Ubiquitous. |
| Function | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. |
| Protein Name | Fanconi Anemia Group C ProteinProtein Facc |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-6796648Reactome: R-HSA-9833482 |
| Cellular Localisation | NucleusCytoplasmThe Major Form Is NuclearThe Minor Form Is Cytoplasmic |
| Alternative Antibody Names | Anti-Fanconi Anemia Group C Protein antibodyAnti-Protein Facc antibodyAnti-FANCC antibodyAnti-FAC antibodyAnti-FACC antibody |
Information sourced from Uniprot.org
