Anti-FASN antibody (1478-1527 aa) (STJ93048)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Fatty Acid Synthase at the amino acid range 1478-1527
General Information
| Short Description | Rabbit polyclonal anti-Fatty acid synthase S-acetyltransferase; S-malonyltransferase; 3-oxoacyl-acyl-carrier-protein synthase; 3-oxoacyl-acyl-carrier-protein reductase; 3-hydroxyacyl-acyl-carrier-protein dehydratase; Enoyl-acyl-carrier-protein reduct |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 100-300WB 1:500-1:2000ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FASN |
| Gene ID | 2194 |
| Uniprot ID | FAS_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Fatty Acid Synthase at the amino acid range 1478-1527 |
| Immunogen Region | 1478-1527 aa |
| Specificity | Fatty Acid Synthase Polyclonal Antibody detects endogenous levels of Fatty Acid Synthase protein. |
Additional Info
| Post Translational Modifications | S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis. |
| Function | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein (ACP) domain. (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. |
| Protein Name | Fatty Acid SynthaseType I Fatty Acid Synthase Includes - Acyl-Carrier-Protein S-Acetyltransferase - Acyl-Carrier-Protein S-Malonyltransferase - 3-Oxoacyl-Acyl-Carrier-Protein Synthase - 3-Oxoacyl-Acyl-Carrier-Protein Reductase - 3-Hydroxyacyl-Acyl-Carrier-Protein Dehydratase - Enoyl-Acyl-Carrier-Protein Reductase - Acyl-Acyl-Carrier-Protein Hydrolase |
| Database Links | Reactome: R-HSA-163765Reactome: R-HSA-199220Reactome: R-HSA-2426168Reactome: R-HSA-75105Reactome: R-HSA-9029558 |
| Cellular Localisation | CytoplasmMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Fatty Acid Synthase antibodyAnti-Type I Fatty Acid Synthase Includes - Acyl-Carrier-Protein S-Acetyltransferase - Acyl-Carrier-Protein S-Malonyltransferase - 3-Oxoacyl-Acyl-Carrier-Protein Synthase - 3-Oxoacyl-Acyl-Carrier-Protein Reductase - 3-Hydroxyacyl-Acyl-Carrier-Protein Dehydratase - Enoyl-Acyl-Carrier-Protein Reductase - Acyl-Acyl-Carrier-Protein Hydrolase antibodyAnti-FASN antibodyAnti-FAS antibody |
Information sourced from Uniprot.org