| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FDXR |
| Gene ID: | 2232 |
| Uniprot ID: | ADRO_HUMAN |
| Immunogen Region: | 142-491 |
| Immunogen Sequence: | EIPGEELPGVCSARAFVGWY NGLPENQELEPDLSCDTAVI LGQGNVALDVARILLTPPEH LERTDITKAALGVLRQSRVK TVWLVGRRGPLQVAFTIKEL REMIQLPGARPILDPVDFLG LQDKIKEVPRPRKRLTELLL RTATEKPGPAEAARQASASR AWGLRFFRSPQQVLPSPDGR RAAGVRLAVTRLEGVDEATR AVPTGDMEDLPCGLVLSSIG YKSRPVDPSVPFDSKLGVI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 142-491 of human Ferredoxin Reductase (NP_077728.3). |
| Function | Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6. |
| Protein Name | Nadph -Adrenodoxin Oxidoreductase - MitochondrialArAdrenodoxin ReductaseFerredoxin--Nadp(+ ReductaseFerredoxin Reductase |
| Database Links | Reactome: R-HSA-196108Reactome: R-HSA-211976Reactome: R-HSA-2395516Reactome: R-HSA-5579026 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Nadph -Adrenodoxin Oxidoreductase - Mitochondrial antibodyAnti-Ar antibodyAnti-Adrenodoxin Reductase antibodyAnti-Ferredoxin--Nadp(+ Reductase antibodyAnti-Ferredoxin Reductase antibodyAnti-FDXR antibodyAnti-ADXR antibody |
Information sourced from Uniprot.org
