| Tissue Specificity | Strongest expression in skeletal muscle with high expression also in the heart and lung. |
| Function | Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments. It also plays a role in the assembly of cardiomyocyte cell adhesion complexes. Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. |
| Protein Name | Protein Flightless-1 Homolog |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionPodosomeCell JunctionFocal AdhesionColocalizes To Actin-Rich Structures In Blastocysts AndTogether With HrasRhoa And Cdc42In Migrating FibroblastsLocalizes To CentrosomesLocalized To The Core Of Macrophage Podosomes |
| Alternative Antibody Names | Anti-Protein Flightless-1 Homolog antibodyAnti-FLII antibodyAnti-FLIL antibody |
Information sourced from Uniprot.org
