Anti-GABBR1 antibody

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Product name Anti-GABBR1 antibody
Short Description Rabbit polyclonal against GABBR1
Description This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined.
Applications WB
Dilution range WB 1:1000 - 1:2000
Protein Name Gamma-Aminobutyric Acid Type B Receptor Subunit 1
Gaba-B Receptor 1
Gaba-B-R1
Gaba-Br1
Gababr1
Gb1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human GABBR1 (NP_068703. 1).
Storage Instruction Store at -20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Gene ID 2550
Gene Symbol GABBR1
Molecular Weight Calculated: 65kDa/95kDa/101kDa/104kDa/108kDa. Observed: 95kDa
Database Links Reactome: R-HSA-1296041
Alternative Names Anti-Gamma-Aminobutyric Acid Type B Receptor Subunit 1 antibody
Anti-Gaba-B Receptor 1 antibody
Anti-Gaba-B-R1 antibody
Anti-Gaba-Br1 antibody
Anti-Gababr1 antibody
Anti-Gb1 antibody
Anti-GABBR1 GPRC3A antibody
Function Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Cell Junction
Synapse
Postsynaptic Cell Membrane
Cell Projection
Dendrite
Colocalizes With Atf4 In Hippocampal Neuron Dendritic Membranes
Coexpression Of Gabbr1 And Gabbr2 Is Required For Gabbr1 Maturation And Transport To The Plasma Membrane
Isoform 1e: Secreted
Tissue Specificity Highly expressed in brain. Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer. Isoform 1B: Mainly expressed in Purkinje cells. Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.
Swiss-Prot Key GABR1_HUMAN
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