Anti-GANAB antibody (1-260) (STJ115790)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GANAB (1-260) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GANAB |
| Gene ID | 23193 |
| Uniprot ID | GANAB_HUMAN |
| Immunogen Region | 1-260 |
| Immunogen Sequence | MTRFRIDELEPRRPRYRVPD VLVADPPIARLSVSGRDENS VELTMAEGPYKIILTARPFR LDLLEDRSLLLSVNARGLLE FEHQRAPRVSQGSKDPAEGD GAQPEETPRDGDKPEETQGK AEKDEPGAWEETFKTHSDSK PYGPMSVGLDFSLPGMEHVY GIPEHADNLRLKVTEGGEPY RLYNLDVFQYELYNPMALYG SVPVLLAHNPHRDLGIFWLN AAETWVDISSNTAGKTLFG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GANAB (NP_001265123.1). |
Additional Info
| Tissue Specificity | Detected in placenta. Isoform 1 and isoform 2 are expressed in the kidney and liver. |
| Function | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia. |
| Protein Name | Neutral Alpha-Glucosidase AbAlpha-Glucosidase 2Glucosidase Ii Subunit Alpha |
| Database Links | Reactome: R-HSA-532668Reactome: R-HSA-901042Reactome: R-HSA-9683686Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Neutral Alpha-Glucosidase Ab antibodyAnti-Alpha-Glucosidase 2 antibodyAnti-Glucosidase Ii Subunit Alpha antibodyAnti-GANAB antibodyAnti-G2AN antibodyAnti-KIAA0088 antibody |
Information sourced from Uniprot.org