| Host: |
Chicken |
| Applications: |
ELISA/WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Chicken polyclonal antibody anti-GFRa-1 is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgY |
| Formulation: |
Concentrated ammonium sulphate in PBS pH 7.4 |
| Purification: |
GFRa-1 affinity purified |
| Dilution Range: |
ELISA 0.02 to 0.05 µg/ml; WB 0.1 to 0.2 µg/ml; IF 0.5 to 1 µg/ml Polyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Storage Instruction: |
Store at +4 °C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use |
| Gene Symbol: |
GFRA1 |
| Gene ID: |
2674 |
| Uniprot ID: |
GFRA1_HUMAN |
| Specificity: |
Human GFRa-1 doesn t cross-react with hGFRa-2, hGFRa-3, hGFRa-4 |
| Immunogen: |
Recombinant His-tagged human GFRa-1 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-1, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w |
| Function | Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-1 antibodyAnti-Gdnf Receptor Alpha-1 antibodyAnti-Gdnfr-Alpha-1 antibodyAnti-Gfr-Alpha-1 antibodyAnti-Ret Ligand 1 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 1 antibodyAnti-GFRA1 antibodyAnti-GDNFRA antibodyAnti-RETL1 antibodyAnti-TRNR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
