Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Ganglioside GM2 activator is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | GM2A |
Gene ID: | 2760 |
Uniprot ID: | SAP3_HUMAN |
Specificity: | This antibody detects endogenous levels of GM2A at Human, Mouse |
Immunogen: | Synthesized peptide derived from human GM2A |
Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity. |
Protein Name | Ganglioside Gm2 Activator Cerebroside Sulfate Activator Protein Gm2-Ap Sphingolipid Activator Protein 3 Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short |
Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-9840310 |
Cellular Localisation | Lysosome |
Alternative Antibody Names | Anti-Ganglioside Gm2 Activator antibody Anti-Cerebroside Sulfate Activator Protein antibody Anti-Gm2-Ap antibody Anti-Sphingolipid Activator Protein 3 antibody Anti-Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short antibody Anti-GM2A antibody |
Information sourced from Uniprot.org