Anti-GNAL antibody (41-90 aa) (STJ93458)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GNAL at the amino acid range 41-90
General Information
| Short Description | Rabbit polyclonal anti-Guanine nucleotide-binding protein Golf subunit alpha (41-90 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNAL |
| Gene ID | 2774 |
| Uniprot ID | GNAL_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GNAL at the amino acid range 41-90 |
| Immunogen Region | 41-90 aa |
| Specificity | G Alpha olf Polyclonal Antibody detects endogenous levels of G Alpha olf protein. |
Additional Info
| Function | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation. Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP. |
| Protein Name | Guanine Nucleotide-Binding Protein G(Olf Subunit AlphaAdenylate Cyclase-Stimulating G Alpha Protein - Olfactory Type |
| Database Links | Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381753 |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(Olf Subunit Alpha antibodyAnti-Adenylate Cyclase-Stimulating G Alpha Protein - Olfactory Type antibodyAnti-GNAL antibody |
Information sourced from Uniprot.org