| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GRB7 (1-140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRB7 |
| Gene ID: |
2886 |
| Uniprot ID: |
GRB7_HUMAN |
| Immunogen Region: |
1-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GRB7 (NP_001229372.1). |
| Immunogen Sequence: |
MELDLSPPHLSSSPEDLCPA PGTPPGTPRPPDTPLPEEVK RSQPLLIPTTGRKLREEERR ATSLPSIPNPFPELCSPPSQ SPILGGPSSARGLLPRDASR PHVVKVYSEDGACRSVEVAA GATARHVCEMLVQRAHALSD |
| Post Translational Modifications | Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress. Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases. |
| Function | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. |
| Protein Name | Growth Factor Receptor-Bound Protein 7B47Epidermal Growth Factor Receptor Grb-7Grb7 Adapter Protein |
| Database Links | Reactome: R-HSA-1306955Reactome: R-HSA-1433557Reactome: R-HSA-186763Reactome: R-HSA-210993Reactome: R-HSA-8853659Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic GranuleCell ProjectionPredominantly CytoplasmicDetected In Stress GranulesWhere Mrna Is Stored Under Stress Conditions |
| Alternative Antibody Names | Anti-Growth Factor Receptor-Bound Protein 7 antibodyAnti-B47 antibodyAnti-Epidermal Growth Factor Receptor Grb-7 antibodyAnti-Grb7 Adapter Protein antibodyAnti-GRB7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
