| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Minor histocompatibility antigen H13 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HM13 |
| Gene ID: | 81502 |
| Uniprot ID: | HM13_HUMAN |
| Specificity: | This antibody detects endogenous levels of SPP at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human SPP |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection. |
| Protein Name | Minor Histocompatibility Antigen H13 Intramembrane Protease 1 Imp-1 Impas-1 Himp1 Presenilin-Like Protein 3 Signal Peptide Peptidase |
| Database Links | Reactome: R-HSA-9707587 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Membrane Lumenal Side Isoform 4: Cell Membrane |
| Alternative Antibody Names | Anti-Minor Histocompatibility Antigen H13 antibody Anti-Intramembrane Protease 1 antibody Anti-Imp-1 antibody Anti-Impas-1 antibody Anti-Himp1 antibody Anti-Presenilin-Like Protein 3 antibody Anti-Signal Peptide Peptidase antibody Anti-HM13 antibody Anti-H13 antibody Anti-IMP1 antibody Anti-PSL3 antibody Anti-SPP antibody Anti-MSTP086 antibody |
Information sourced from Uniprot.org