| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HSPB8 |
| Gene ID: | 26353 |
| Uniprot ID: | HSPB8_HUMAN |
| Immunogen Region: | 1-196 |
| Immunogen Sequence: | MADGQMPFSCHYPSRLRRDP FRDSPLSSRLLDDGFGMDPF PDDLTASWPDWALPRLSSAW PGTLRSGMVPRGPTATARFG VPAEGRTPPPFPGEPWKVCV NVHSFKPEELMVKTKDGYVE VSGKHEEKQQEGGIVSKNFT KKIQLPAEVDPVTVFASLSP EGLLIIEAPQVPPYSTFGES SFNNELPQDSQEVTCT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human HSPB8/HSP22 (NP_055180.1). |
| Tissue Specificity | Predominantly expressed in skeletal muscle and heart. |
| Function | Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. |
| Protein Name | Heat Shock Protein Beta-8Hspb8Alpha-Crystallin C ChainE2-Induced Gene 1 ProteinHeat Shock Protein Family B Member 8Protein Kinase H11Small Stress Protein-Like Protein Hsp22 |
| Database Links | Reactome: R-HSA-3371571 |
| Cellular Localisation | CytoplasmNucleusTranslocates To Nuclear Foci During Heat Shock |
| Alternative Antibody Names | Anti-Heat Shock Protein Beta-8 antibodyAnti-Hspb8 antibodyAnti-Alpha-Crystallin C Chain antibodyAnti-E2-Induced Gene 1 Protein antibodyAnti-Heat Shock Protein Family B Member 8 antibodyAnti-Protein Kinase H11 antibodyAnti-Small Stress Protein-Like Protein Hsp22 antibodyAnti-HSPB8 antibodyAnti-CRYAC antibodyAnti-E2IG1 antibodyAnti-HSP22 antibodyAnti-PP1629 antibody |
Information sourced from Uniprot.org
