| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HTRA3 (334-453) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HTRA3 |
| Gene ID: |
94031 |
| Uniprot ID: |
HTRA3_HUMAN |
| Immunogen Region: |
334-453 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1). |
| Immunogen Sequence: |
SDRITRFLTEFQDKQIKDWK KRFIGIRMRTITPSLVDELK ASNPDFPEVSSGIYVQEVAP NSPSQRGGIQDGDIIVKVNG RPLVDSSELQEAVLTESPLL LEVRRGNDDLLFSIAPEVVM |
| Tissue Specificity | Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. |
| Function | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. |
| Protein Name | Serine Protease Htra3High-Temperature Requirement Factor A3Pregnancy-Related Serine Protease |
| Cellular Localisation | SecretedSecretion Increased During Decidualization Of Endometrial Stromal Cells |
| Alternative Antibody Names | Anti-Serine Protease Htra3 antibodyAnti-High-Temperature Requirement Factor A3 antibodyAnti-Pregnancy-Related Serine Protease antibodyAnti-HTRA3 antibodyAnti-PRSP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
