Anti-IFNL1 antibody (20-200) (STJ110587)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IFNL1 (20-200) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFNL1 |
| Gene ID | 282618 |
| Uniprot ID | IFNL1_HUMAN |
| Immunogen Region | 20-200 |
| Immunogen Sequence | GPVPTSKPTTTGKGCHIGRF KSLSPQELASFKKARDALEE SLKLKNWSCSSPVFPGNWDL RLLQVRERPVALEAELALTL KVLEAAAGPALEDVLDQPLH TLHHILSQLQACIQPQPTAG PRPRGRLHHWLHRLQEAPKK ESAGCLEASVTFNLFRLLTR DLKYVADGNLCLRTSTHPES T |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human IFNL1 (NP_742152.1). |
Additional Info
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-1Ifn-Lambda-1Cytokine Zcyto21Interleukin-29Il-29 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Lambda-1 antibodyAnti-Ifn-Lambda-1 antibodyAnti-Cytokine Zcyto21 antibodyAnti-Interleukin-29 antibodyAnti-Il-29 antibodyAnti-IFNL1 antibodyAnti-IL29 antibodyAnti-ZCYTO21 antibody |
Information sourced from Uniprot.org