Anti-IKAP antibody (1280-1330) {FITC} (STJ501410)

SKU:
STJ501410-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IKAP (1280-1330) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgY
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Elp1
Gene ID: 230233
Uniprot ID: ELP1_MOUSE
Immunogen Region: 1280-1330
Immunogen: Synthetic peptide taken within amino acid region 1280-1330 on mouse Elongator Complex Protein 1.
Tissue Specificity In the testis, expression is restricted to germ cells during spermatogenesis with no expression detected in somatic cells such as Sertoli cells or Leydig cells (at protein level). In the ovary, expressed in oocytes of primary, secondary and antral follicles (at protein level). Widely expressed in adult tissues with highest levels in brain and also expressed at all embryonic stages.
Post Translational Modifications Phosphorylated.
Function Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).
Protein Name Elongator Complex Protein 1
Elp1
Ikappab Kinase Complex-Associated Protein
Ikk Complex-Associated Protein
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Elongator Complex Protein 1 antibody
Anti-Elp1 antibody
Anti-Ikappab Kinase Complex-Associated Protein antibody
Anti-Ikk Complex-Associated Protein antibody
Anti-Elp1 antibody
Anti-Ikap antibody
Anti-Ikbkap antibody

Information sourced from Uniprot.org

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