| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL31 (24-164) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL31 |
| Gene ID: |
386653 |
| Uniprot ID: |
IL31_HUMAN |
| Immunogen Region: |
24-164 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-164 of human IL31 (NP_001014358.1). |
| Immunogen Sequence: |
SHTLPVRLLRPSDDVQKIVE ELQSLSKMLLKDVEEEKGVL VSQNYTLPCLSPDAQPPNNI HSPAIRAYLKTIRQLDNKSV IDEIIEHLDKLIFQDAPETN ISVPTDTHECKRFILTISQQ FSECMDLALKSLTSGAQQAT T |
| Tissue Specificity | Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. |
| Function | Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages. |
| Protein Name | Interleukin-31Il-31 |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-31 antibodyAnti-Il-31 antibodyAnti-IL31 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
