Anti-IMPDH1 antibody (434-563) (STJ111723)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IMPDH1 (434-563) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IMPDH1 |
| Gene ID | 3614 |
| Uniprot ID | IMDH1_HUMAN |
| Immunogen Region | 434-563 |
| Immunogen Sequence | MMGSLLAATTEAPGEYFFSD GVRLKKYRGMGSLDAMEKSS SSQKRYFSEGDKVKIAQGVS GSIQDKGSIQKFVPYLIAGI QHGCQDIGARSLSVLRSMMY SGELKFEKRTMSAQIEGGVH GLHSYEKRLY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 434-563 of human IMPDH1 (NP_899066.1). |
Additional Info
| Tissue Specificity | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 1Imp Dehydrogenase 1Impd 1Impdh 1Impdh-I |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-73817Reactome: R-HSA-9679191Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Inosine-5'-Monophosphate Dehydrogenase 1 antibodyAnti-Imp Dehydrogenase 1 antibodyAnti-Impd 1 antibodyAnti-Impdh 1 antibodyAnti-Impdh-I antibodyAnti-IMPDH1 antibodyAnti-IMPD1 antibody |
Information sourced from Uniprot.org