| Tissue Specificity | Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney. |
| Function | Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases.therefore, is the specific regulator for insulin signaling in skeletal muscle. |
| Protein Name | Inositol Polyphosphate 5-Phosphatase KPhosphatidylinositol-3 -4 -5-Trisphosphate 5-PhosphatasePhosphatidylinositol-4 -5-Bisphosphate 5-PhosphataseSkeletal Muscle And Kidney-Enriched Inositol Phosphatase |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | Endoplasmic ReticulumCytoplasmFollowing Stimulation With EgfTranslocates To Membrane RufflesConcentrated At The Periphery Of The Nucleus |
| Alternative Antibody Names | Anti-Inositol Polyphosphate 5-Phosphatase K antibodyAnti-Phosphatidylinositol-3 -4 -5-Trisphosphate 5-Phosphatase antibodyAnti-Phosphatidylinositol-4 -5-Bisphosphate 5-Phosphatase antibodyAnti-Skeletal Muscle And Kidney-Enriched Inositol Phosphatase antibodyAnti-INPP5K antibodyAnti-PPS antibodyAnti-SKIP antibody |
Information sourced from Uniprot.org
