| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ITGA2B (693-993) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITGA2B |
| Gene ID: |
3674 |
| Uniprot ID: |
ITA2B_HUMAN |
| Immunogen Region: |
693-993 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human CD41/CD41/ITGA2B (NP_000410.2). |
| Immunogen Sequence: |
ALSNVEGFERLICNQKKENE TRVVLCELGNPMKKNAQIGI AMLVSVGNLEEAGESVSFQL QIRSKNSQNPNSKIVLLDVP VRAEAQVELRGNSFPASLVV AAEEGEREQNSLDSWGPKVE HTYELHNNGPGTVNGLHLSI HLPGQSQPSDLLYILDIQPQ GGLQCFPQPPVNPLKVDWGL PIPSPSPIHPAHHKRDRRQI FLPEPEQPSRLQDPVLVSCD SAPCTVVQCDLQEMARGQR |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines. Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level). |
| Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
| Protein Name | Integrin Alpha-IibGpalpha IibGpiibPlatelet Membrane Glycoprotein IibCd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-216083Reactome: R-HSA-3000178Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-445144Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8936459Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-Iib antibodyAnti-Gpalpha Iib antibodyAnti-Gpiib antibodyAnti-Platelet Membrane Glycoprotein Iib antibodyAnti-Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 antibodyAnti-ITGA2B antibodyAnti-GP2B antibodyAnti-ITGAB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
