| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNMB2 (68-194) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNMB2 |
| Gene ID: |
10242 |
| Uniprot ID: |
KCMB2_HUMAN |
| Immunogen Region: |
68-194 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 68-194 of human KCNMB2 (NP_005823.1). |
| Immunogen Sequence: |
TLLRSYMQSVWTEESQCTLL NASITETFNCSFSCGPDCWK LSQYPCLQVYVNLTSSGEKL LLYHTEETIKINQKCSYIPK CGKNFEESMSLVNVVMENFR KYQHFSCYSDPEGNQKSVIL TKLYSSN |
| Tissue Specificity | Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. |
| Protein Name | Calcium-Activated Potassium Channel Subunit Beta-2Bk Channel Subunit Beta-2Bkbeta2Hbeta2Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-2Charybdotoxin Receptor Subunit Beta-2Hbeta3K(Vcabeta-2Maxi K Channel Subunit Beta-2Slo-Beta-2 |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Beta-2 antibodyAnti-Bk Channel Subunit Beta-2 antibodyAnti-Bkbeta2 antibodyAnti-Hbeta2 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-2 antibodyAnti-Charybdotoxin Receptor Subunit Beta-2 antibodyAnti-Hbeta3 antibodyAnti-K(Vcabeta-2 antibodyAnti-Maxi K Channel Subunit Beta-2 antibodyAnti-Slo-Beta-2 antibodyAnti-KCNMB2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
