| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KLF10 (161-365) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KLF10 |
| Gene ID: |
7071 |
| Uniprot ID: |
KLF10_HUMAN |
| Immunogen Region: |
161-365 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 161-365 of human KLF10 (NP_001027453.1). |
| Immunogen Sequence: |
MKAASILNYQNNSFRRRTHL NVEAARKNIPCAAVSPNRSK CERNTVADVDEKASAALYDF SVPSSETVICRSQPAPVSPQ QKSVLVSPPAVSAGGVPPMP VICQMVPLPANNPVVTTVVP STPPSQPPAVCPPVVFMGTQ VPKGAVMFVVPQPVVQSSKP PVVSPNGTRLSPIAPAPGFS PSAAKVTPQIDSSRIRSHIC SHPGC |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. |
| Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock.binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation. |
| Protein Name | Krueppel-Like Factor 10Egr-AlphaTransforming Growth Factor-Beta-Inducible Early Growth Response Protein 1Tgfb-Inducible Early Growth Response Protein 1Tieg-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 10 antibodyAnti-Egr-Alpha antibodyAnti-Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1 antibodyAnti-Tgfb-Inducible Early Growth Response Protein 1 antibodyAnti-Tieg-1 antibodyAnti-KLF10 antibodyAnti-TIEG antibodyAnti-TIEG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
