| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | KMT5C |
| Gene ID: | 84787 |
| Uniprot ID: | KMT5C_HUMAN |
| Immunogen Region: | 2-248 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 2-248 of human KMT5C (NP_116090.2). |
| Immunogen Sequence: | GPDRVTARELCENDDLATSL VLDPYLGFRTHKMNVSPVPP LRRQQHLRSALETFLRQRDL EAAYRALTLGGWTARYFQSR GPRQEAALKTHVYRYLRAFL PESGFTILPCTRYSMETNGA KIVSTRAWKKNEKLELLVGC IAELREADEGLLRAGENDFS IMYSTRKRSAQLWLGPAAFI NHDCKPNCKFVPADGNAACV KVLRDIEPGDEVTCFYGEGF FGEKNEHCECHTCERKGEG |
| Function | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. |
| Protein Name | Histone-Lysine N-Methyltransferase Kmt5c Lysine N-Methyltransferase 5c Lysine-Specific Methyltransferase 5c Suppressor Of Variegation 4-20 Homolog 2 Su(Var4-20 Homolog 2 Suv4-20h2 Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5b Histone H4-Lysine20 N-Methyltransferase Kmt5b |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | Nucleus Chromosome Associated With Pericentric Heterochromatin Cbx1 And Cbx5 Are Required For The Localization To Pericentric Heterochromatin |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Kmt5c antibody Anti-Lysine N-Methyltransferase 5c antibody Anti-Lysine-Specific Methyltransferase 5c antibody Anti-Suppressor Of Variegation 4-20 Homolog 2 antibody Anti-Su(Var4-20 Homolog 2 antibody Anti-Suv4-20h2 antibody Anti-Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5b antibody Anti-Histone H4-Lysine20 N-Methyltransferase Kmt5b antibody Anti-KMT5C antibody Anti-SUV420H2 antibody Anti-PP7130 antibody |
Information sourced from Uniprot.org