| Tissue Specificity | Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. |
| Post Translational Modifications | Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections. |
| Function | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. |
| Protein Name | Plastin-2L-PlastinLc64pLymphocyte Cytosolic Protein 1Lcp-1 |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideRelocalizes To The Immunological Synapse Between Peripheral Blood T-Lymphocytes And Antibody-Presenting Cells In Response To Costimulation Through Tcr/Cd3 And Cd2 Or Cd28Associated With The Actin Cytoskeleton At Membrane RufflesRelocalizes To Actin-Rich Cell Projections Upon Serine Phosphorylation |
| Alternative Antibody Names | Anti-Plastin-2 antibodyAnti-L-Plastin antibodyAnti-Lc64p antibodyAnti-Lymphocyte Cytosolic Protein 1 antibodyAnti-Lcp-1 antibodyAnti-LCP1 antibodyAnti-PLS2 antibody |
Information sourced from Uniprot.org
