| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LTA |
| Gene ID: | 4049 |
| Uniprot ID: | TNFB_HUMAN |
| Immunogen Region: | 35-205 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-205 of human LTA (NP_000586.2). |
| Immunogen Sequence: | LPGVGLTPSAAQTARQHPKM HLAHSTLKPAAHLIGDPSKQ NSLLWRANTDRAFLQDGFSL SNNSLLVPTSGIYFVYSQVV FSGKAYSPKATSSPLYLAHE VQLFSSQYPFHVPLLSSQKM VYPGLQEPWLHSMYHGAAFQ LTQGDQLSTHTDGIPHLVLS PSTVFFGAFAL |
| Function | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. |
| Protein Name | Lymphotoxin-AlphaLt-AlphaTnf-BetaTumor Necrosis Factor Ligand Superfamily Member 1 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | SecretedMembraneThe Homotrimer Is SecretedThe Heterotrimer Is Membrane-Associated |
| Alternative Antibody Names | Anti-Lymphotoxin-Alpha antibodyAnti-Lt-Alpha antibodyAnti-Tnf-Beta antibodyAnti-Tumor Necrosis Factor Ligand Superfamily Member 1 antibodyAnti-LTA antibodyAnti-TNFB antibodyAnti-TNFSF1 antibody |
Information sourced from Uniprot.org
