Anti-MAGEA6 antibody (75-314) (STJ116318)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAGEA6 (75-314) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAGEA6 |
| Gene ID | 4105 |
| Uniprot ID | MAGA6_HUMAN |
| Immunogen Region | 75-314 |
| Immunogen Sequence | MNYPLWSQSYEDSSNQEEEG PSTFPDLESEFQAALSRKVA KLVHFLLLKYRAREPVTKAE MLGSVVGNWQYFFPVIFSKA SDSLQLVFGIELMEVDPIGH VYIFATCLGLSYDGLLGDNQ IMPKTGFLIIILAIIAKEGD CAPEEKIWEELSVLEVFEGR EDSIFGDPKKLLTQYFVQEN YLEYRQVPGSDPACYEFLWG PRALIETSYVKVLHHMVKIS GGPRISYPLLHEWALREGE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 75-314 of human MAGEA6 (NP_005354.1). |
Additional Info
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. |
| Post Translational Modifications | Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. |
| Function | Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. |
| Protein Name | Melanoma-Associated Antigen 6Cancer/Testis Antigen 1.6Ct1.6Mage-6 AntigenMage3b Antigen |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen 6 antibodyAnti-Cancer/Testis Antigen 1.6 antibodyAnti-Ct1.6 antibodyAnti-Mage-6 Antigen antibodyAnti-Mage3b Antigen antibodyAnti-MAGEA6 antibodyAnti-MAGE6 antibody |
Information sourced from Uniprot.org