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Anti-MMP9 Antibody

[STJ24592] Download PDF Print Data Sheet
5-7 days

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Product name Anti-MMP9 Antibody
Short Description Rabbit polyclonal to MMP9
Description Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Applications IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
Protein Name Matrix metalloproteinase-9
MMP-9
Immunogen A synthetic peptide of human MMP9
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 4318
Gene Symbol MMP9
Molecular Weight 78.458 kDa
Database Links HGNC:7176
OMIM:120361
Reactome:R-HSA-1433557
Alternative Names Matrix metalloproteinase-9 antibody
MMP-9 antibody
CLG4B antibody
Function May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration, Could play a role in bone osteoclastic resorption, Cleaves KiSS1 at a Gly-|-Leu bond, Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments, Degrades fibronectin but not laminin or Pz-peptide,
Post-translational Modifications Processing of the precursor yields different active forms of 64, 67 and 82 kDa, Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9,
Cellular Localization Secreted, extracellular space, extracellular matrix
Tissue Specificity Produced by normal alveolar macrophages and granulocytes
Swiss-Prot Key P14780
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