| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MRGPRX1 (263-322) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MRGPRX1 |
| Gene ID: |
259249 |
| Uniprot ID: |
MRGX1_HUMAN |
| Immunogen Region: |
263-322 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 263-322 of human MRGPRX1 (NP_671732.3). |
| Immunogen Sequence: |
LNSSANPIIYFFVGSFRQRQ NRQNLKLVLQRALQDASEVD EGGGQLPEEILELSGSRLEQ |
| Tissue Specificity | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. |
| Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. |
| Protein Name | Mas-Related G-Protein Coupled Receptor Member X1Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mas-Related G-Protein Coupled Receptor Member X1 antibodyAnti-Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 antibodyAnti-MRGPRX1 antibodyAnti-MRGX1 antibodyAnti-SNSR3 antibodyAnti-SNSR4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
