Anti-MRP3 antibody [M3II-21] (STJ16100897)

SKU:
STJ16100897-1

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Host: Mouse
Applications: ICC/IHC-F/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MRP3 is suitable for use in Immunocytochemistry, Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: M3II-21
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: supernatant with 0.7% BSA and 0.1% sodium azide
Concentration: 250 ug/mL
Dilution Range: ICC 1:20-1:50
IHC 1:20
WB 1:20-1:50
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: ABCC3
Gene ID: 8714
Uniprot ID: MRP3_HUMAN
Immunogen: MRP3 aa 830-949
Tissue Specificity Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules.
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.
Protein Name Atp-Binding Cassette Sub-Family C Member 3
Canalicular Multispecific Organic Anion Transporter 2
Multi-Specific Organic Anion Transporter D
Moat-D
Multidrug Resistance-Associated Protein 3
Database Links Reactome: R-HSA-159418
Reactome: R-HSA-382556
Reactome: R-HSA-9749641
Reactome: R-HSA-9753281
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Basal Cell Membrane
Localized To The Basolateral Membrane Of Enterocytes
Localized To The Basal Membrane Of Sertoli Cells
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 3 antibody
Anti-Canalicular Multispecific Organic Anion Transporter 2 antibody
Anti-Multi-Specific Organic Anion Transporter D antibody
Anti-Moat-D antibody
Anti-Multidrug Resistance-Associated Protein 3 antibody
Anti-ABCC3 antibody
Anti-CMOAT2 antibody
Anti-MLP2 antibody
Anti-MRP3 antibody

Information sourced from Uniprot.org

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