| Post Translational Modifications | Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by some Cul2-RING E3 ubiquitin-protein ligase complexes (containing either PRAME, PRAMF6, PRAMF9 or FEM1C as substrate-recognition component). |
| Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. |
| Protein Name | Methionine-R-Sulfoxide Reductase B1Msrb1Selenoprotein XSelx |
| Database Links | Reactome: R-HSA-5676934 |
| Cellular Localisation | CytoplasmNucleusCytoskeleton |
| Alternative Antibody Names | Anti-Methionine-R-Sulfoxide Reductase B1 antibodyAnti-Msrb1 antibodyAnti-Selenoprotein X antibodyAnti-Selx antibodyAnti-MSRB1 antibodyAnti-SEPX1 antibodyAnti-HSPC270 antibody |
Information sourced from Uniprot.org
