| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NECAB3 |
| Gene ID: | 63941 |
| Uniprot ID: | NECA3_HUMAN |
| Immunogen Region: | 1-362 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-362 of human NECAB3 (NP_112508.3). |
| Immunogen Sequence: | MACAGLLTVCLLRPPAPQPQ PQTPRHPQLAPDPGPAGHTL FQDVFRRADKNDDGKLSFEE FQNYFADGVLSLGELQELFS GIDGHLTDNLETEKLCDYFS EHLGVYRPVLAALESLNRAV LAAMDATKLEYERASKVDQF VTRFLLRETVSQLQALQSSL EGASDTLEAQAHGWRSDAES VEAQSRLCGSRRAGRRALRS VSRSSTWSPGSSDTGRSSEA EMQWRLQVNRLQELIDQLE |
| Tissue Specificity | Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. |
| Post Translational Modifications | Phosphorylated by NEK2. |
| Function | Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions.the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3. |
| Protein Name | N-Terminal Ef-Hand Calcium-Binding Protein 3 Amyloid-Beta A4 Protein-Binding Family A Member 2-Binding Protein Nek2-Interacting Protein 1 Neuronal Calcium-Binding Protein 3 X11l-Binding Protein 51 |
| Cellular Localisation | Golgi Apparatus |
| Alternative Antibody Names | Anti-N-Terminal Ef-Hand Calcium-Binding Protein 3 antibody Anti-Amyloid-Beta A4 Protein-Binding Family A Member 2-Binding Protein antibody Anti-Nek2-Interacting Protein 1 antibody Anti-Neuronal Calcium-Binding Protein 3 antibody Anti-X11l-Binding Protein 51 antibody Anti-NECAB3 antibody Anti-APBA2BP antibody Anti-NIP1 antibody Anti-SYTIP2 antibody Anti-XB51 antibody |
Information sourced from Uniprot.org