| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NFAM1 (186-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NFAM1 |
| Gene ID: |
150372 |
| Uniprot ID: |
NFAM1_HUMAN |
| Immunogen Region: |
186-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 186-270 of human NFAM1 (NP_666017.1). |
| Immunogen Sequence: |
WNKKRMRGPGKDPTRKCPDP RSASSPKQHPSESVYTALQR RETEVYACIENEDGSSPTAK QSPLSQERPHRFEDDGELNL VYENL |
| Tissue Specificity | Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue. |
| Post Translational Modifications | N-glycosylated. |
| Function | May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. |
| Protein Name | Nfat Activation Molecule 1Calcineurin/Nfat-Activating Itam-Containing ProteinNfat-Activating Protein With Itam Motif 1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPartially Recruited To Lipid Rafts Upon Bcr Stimulation |
| Alternative Antibody Names | Anti-Nfat Activation Molecule 1 antibodyAnti-Calcineurin/Nfat-Activating Itam-Containing Protein antibodyAnti-Nfat-Activating Protein With Itam Motif 1 antibodyAnti-NFAM1 antibodyAnti-CNAIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
