Anti-NGF antibody

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Product name Anti-NGF antibody
Short Description Rabbit polyclonal against NGF
Description Rabbit polyclonal to NGF.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Specificity NGF polyclonal antibody detects endogenous levels of NGF protein.
Protein Name Beta-Nerve Growth Factor
Beta-Ngf
Immunogen Synthesized peptide derived from human NGF.
Immunogen Region Internal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4803
Gene Symbol NGF
Molecular Weight 27 kDa
Database Links HGNC:7808
OMIM:162030
Alternative Names Anti-Beta-Nerve Growth Factor antibody
Anti-Beta-Ngf antibody
Anti-NGF NGFB antibody
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.
Cellular Localization Secreted
Endosome Lumen
Prongf Is Endocytosed After Binding To The Cell Surface Receptor Formed By Sort1 And Ngfr
Swiss-Prot Key NGF_HUMAN
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