| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NOX3 |
| Gene ID: | 50508 |
| Uniprot ID: | NOX3_HUMAN |
| Immunogen Region: | 223-395 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-395 of human NOX3 (NP_056533.1). |
| Immunogen Sequence: | GRIVRGQTQDSLSLHNITFC RDRYAEWQTVAQCPVPQFSG KEPSAWKWILGPVVLYACER IIRFWRFQQEVVITKVVSHP SGVLELHMKKRGFKMAPGQY ILVQCPAISSLEWHPFTLTS APQEDFFSVHIRAAGDWTAA LLEAFGAEGQALQEPWSLPR LAVDGPFGTALTD |
| Post Translational Modifications | N-glycosylated in a CYBA/p22phox-dependent manner. |
| Function | NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. |
| Protein Name | Nadph Oxidase 3 Mitogenic Oxidase 2 Mox-2 Gp91phox Homolog 3 Gp91-3 |
| Database Links | Reactome: R-HSA-5668599 Reactome: R-HSA-9013149 Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Nadph Oxidase 3 antibody Anti-Mitogenic Oxidase 2 antibody Anti-Mox-2 antibody Anti-Gp91phox Homolog 3 antibody Anti-Gp91-3 antibody Anti-NOX3 antibody Anti-MOX2 antibody |
Information sourced from Uniprot.org