| Host: |
Rabbit |
| Applications: |
WB/IP |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NR2E1 (106-385) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IP 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NR2E1 |
| Gene ID: |
7101 |
| Uniprot ID: |
NR2E1_HUMAN |
| Immunogen Region: |
106-385 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 106-385 of human NR2E1/TLX (NP_003260.1). |
| Immunogen Sequence: |
YFRGHKEENGAAAHFPSAAL PAPAFFTAVTQLEPHGLELA AVSTTPERQTLVSLAQPTPK YPHEVNGTPMYLYEVATESV CESAARLLFMSIKWAKSVPA FSTLSLQDQLMLLEDAWREL FVLGIAQWAIPVDANTLLAV SGMNGDNTDSQKLNKIISEI QALQEVVARFRQLRLDATEF ACLKCIVTFKAVPTHSGSEL RSFRNAAAIAALQDEAQLTL NSYIHTRYPTQPCRFGKLL |
| Tissue Specificity | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells. |
| Protein Name | Nuclear Receptor Subfamily 2 Group E Member 1Nuclear Receptor TlxProtein Tailless HomologTllHtll |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-8943724 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 2 Group E Member 1 antibodyAnti-Nuclear Receptor Tlx antibodyAnti-Protein Tailless Homolog antibodyAnti-Tll antibodyAnti-Htll antibodyAnti-NR2E1 antibodyAnti-TLX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
