| Function | ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively. |
| Protein Name | Adp-Ribose Glycohydrolase Oard1O-Acetyl-Adp-Ribose Deacetylase 1Terminal Adp-Ribose Protein Glycohydrolase 1Protein Adp-Ribosylglutamate Hydrolase Oard1 |
| Cellular Localisation | NucleusNucleoplasmNucleolusChromosomeLocalizes Both In The Nucleoplasm And In The NucleolusRelocalizes To The Nucleoplasm In Response To Dna DamageRecruited To Dna Lesion Regions Following Dna Damage |
| Alternative Antibody Names | Anti-Adp-Ribose Glycohydrolase Oard1 antibodyAnti-O-Acetyl-Adp-Ribose Deacetylase 1 antibodyAnti-Terminal Adp-Ribose Protein Glycohydrolase 1 antibodyAnti-Protein Adp-Ribosylglutamate Hydrolase Oard1 antibodyAnti-OARD1 antibodyAnti-C6orf130 antibodyAnti-TARG1 antibody |
Information sourced from Uniprot.org
