| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE12 |
| Gene ID: | 201626 |
| Uniprot ID: | PDE12_HUMAN |
| Immunogen Region: | 17-300 |
| Immunogen Sequence: | AVEKLSRAEAGSQTAAGAME RAVVRCVPSEPKLSLSFALA DGSHKNMQRDQSEPLGRVLS RIATNALKGHAKAAAAKKSR KSRPNASGGAACSGPGPEPA VFCEPVVKLYYREEAVAEDV LNVDAWQDGAVLQIGDVKYK VERNPPAFTELQLPRYIMAG FPVCPKLSLEFGDPASSLFR WYKEAKPGAAEPEVGVPSSL SPSSPSSSWTETDVEERVYT PSNADIGLRLKLHCTPGDG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1). |
| Tissue Specificity | Ubiquitous. |
| Function | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells. |
| Protein Name | 2' -5'-Phosphodiesterase 122'-Pde2-PdeMitochondrial Deadenylase |
| Database Links | Reactome: R-HSA-8983711 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-2' -5'-Phosphodiesterase 12 antibodyAnti-2'-Pde antibodyAnti-2-Pde antibodyAnti-Mitochondrial Deadenylase antibodyAnti-PDE12 antibody |
Information sourced from Uniprot.org
