Anti-PDE12 antibody (17-300) (STJ11102898)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PDE12 (17-300) antibody for use in WB, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE12 |
| Gene ID | 201626 |
| Uniprot ID | PDE12_HUMAN |
| Immunogen Region | 17-300 |
| Immunogen Sequence | AVEKLSRAEAGSQTAAGAME RAVVRCVPSEPKLSLSFALA DGSHKNMQRDQSEPLGRVLS RIATNALKGHAKAAAAKKSR KSRPNASGGAACSGPGPEPA VFCEPVVKLYYREEAVAEDV LNVDAWQDGAVLQIGDVKYK VERNPPAFTELQLPRYIMAG FPVCPKLSLEFGDPASSLFR WYKEAKPGAAEPEVGVPSSL SPSSPSSSWTETDVEERVYT PSNADIGLRLKLHCTPGDG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells. |
| Protein Name | 2' -5'-Phosphodiesterase 122'-Pde2-PdeMitochondrial Deadenylase |
| Database Links | Reactome: R-HSA-8983711 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-2' -5'-Phosphodiesterase 12 antibodyAnti-2'-Pde antibodyAnti-2-Pde antibodyAnti-Mitochondrial Deadenylase antibodyAnti-PDE12 antibody |
Information sourced from Uniprot.org