| Function | Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. |
| Protein Name | PejvakinAutosomal Recessive Deafness Type 59 Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Peroxisome MembraneCell ProjectionCiliumAssociates With The Peroxisomal MembraneIt Is Unclear Whether It Is Embedded Or Just Associated With The Peroxisomal MembraneLocalizes To Ciliary Rootlet |
| Alternative Antibody Names | Anti-Pejvakin antibodyAnti-Autosomal Recessive Deafness Type 59 Protein antibodyAnti-PJVK antibodyAnti-DFNB59 antibody |
Information sourced from Uniprot.org
