| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLA2G4D |
| Gene ID: | 283748 |
| Uniprot ID: | PA24D_HUMAN |
| Immunogen Region: | 510-680 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-680 of human PLA2G4D (NP_828848.3). |
| Immunogen Sequence: | RLMRRIPEPRICFLEAIWSN IFSLNLLDAWYDLTSSGESW KQHIKDKTRSLEKEPLTTSG TSSRLEASWLQPGTALAQAF KGFLTGRPLHQRSPNFLQGL QLHQDYCSHKDFSTWADYQL DSMPSQLTPKEPRLCLVDAA YFINTSSPSMFRPGRRLDLI LSFDYSLSAPF |
| Tissue Specificity | Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. |
| Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. |
| Protein Name | Cytosolic Phospholipase A2 Delta Cpla2-Delta Phospholipase A2 Group Ivd |
| Database Links | Reactome: R-HSA-1482788 Reactome: R-HSA-1482801 Reactome: R-HSA-1482839 Reactome: R-HSA-1482922 Reactome: R-HSA-1482925 Reactome: R-HSA-1483115 Reactome: R-HSA-1483166 |
| Cellular Localisation | Cytoplasm Cytosol Membrane Peripheral Membrane Protein Cytoplasmic Side Translocates To Perinuclear Membranes That May Correspond To Endoplasmic Reticulum Or Golgi In A Calcium-Dependent Fashion |
| Alternative Antibody Names | Anti-Cytosolic Phospholipase A2 Delta antibody Anti-Cpla2-Delta antibody Anti-Phospholipase A2 Group Ivd antibody Anti-PLA2G4D antibody |
Information sourced from Uniprot.org