| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5088RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLAUR |
| Gene ID: | 5329 |
| Uniprot ID: | UPAR_HUMAN |
| Specificity: | Recombinant protein of human uPAR/U-PAR. |
| Immunogen Sequence: | LRCMQCKTNGDCRVEECALG QDLCRTTIVRLWEEGEELEL VEKSCTHSEKTNRTLSYRTG LKITSLTEVVCGLDLCNQGN SGRAVTYSRSRYLECISCGS SDMSCERGRHQSLQCRSPEE QCLDVVTHWIQEGEEGRPKD DRHLRGCGYLPGCPGSNGFH NNDTFHFLKCCNTTKCNEGP ILELENLPQNGRQCYSCKGN STHGCSSEETFLIDCRGPMN QCLVATGTHEPKNQSYMVR |
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Protein Name | Urokinase Plasminogen Activator Surface Receptor U-Par Upar Monocyte Activation Antigen Mo3 Cd Antigen Cd87 |
| Database Links | Reactome: R-HSA-162791 Reactome: R-HSA-6798695 Reactome: R-HSA-75205 |
| Cellular Localisation | Cell Membrane Cell Projection Invadopodium Membrane Colocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton- Integrin- And Vitronectin-Dependent Manner Isoform 1: Cell Membrane Lipid-Anchor Gpi-Anchor Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Urokinase Plasminogen Activator Surface Receptor antibody Anti-U-Par antibody Anti-Upar antibody Anti-Monocyte Activation Antigen Mo3 antibody Anti-Cd Antigen Cd87 antibody Anti-PLAUR antibody Anti-MO3 antibody Anti-UPAR antibody |
Information sourced from Uniprot.org