| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POGLUT1 |
| Gene ID: | 56983 |
| Uniprot ID: | PGLT1_HUMAN |
| Immunogen Region: | 160-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-280 of human POGLUT1 (NP_689518.1). |
| Immunogen Sequence: | MYPAWTFWEGGPAVWPIYPT GLGRWDLFREDLVRSAAQWP WKKKNSTAYFRGSRTSPERD PLILLSRKNPKLVDAEYTKN QAWKSMKDTLGKPAAKDVHL VDHCKYKYLFNFRGVAASFR F |
| Tissue Specificity | Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level). |
| Function | Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane. |
| Protein Name | Protein O-Glucosyltransferase 1 Cap10-Like 46 Kda Protein Hclp46 Ktel Motif-Containing Protein 1 Myelodysplastic Syndromes Relative Protein O-Glucosyltransferase Rumi Homolog Hrumi Protein O-Xylosyltransferase Poglut1 |
| Database Links | Reactome: R-HSA-1912399 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Protein O-Glucosyltransferase 1 antibody Anti-Cap10-Like 46 Kda Protein antibody Anti-Hclp46 antibody Anti-Ktel Motif-Containing Protein 1 antibody Anti-Myelodysplastic Syndromes Relative Protein antibody Anti-O-Glucosyltransferase Rumi Homolog antibody Anti-Hrumi antibody Anti-Protein O-Xylosyltransferase Poglut1 antibody Anti-POGLUT1 antibody Anti-C3orf9 antibody Anti-CLP46 antibody Anti-KTELC1 antibody Anti-MDSRP antibody Anti-MDS010 antibody Anti-UNQ490 antibody Anti-PRO1006 antibody |
Information sourced from Uniprot.org
