| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PORCN (220-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PORCN |
| Gene ID: |
64840 |
| Uniprot ID: |
PORCN_HUMAN |
| Immunogen Region: |
220-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-320 of human PORCN (NP_982299.1). |
| Immunogen Sequence: |
PLNGDRLLRNKKRKARWLRA YESAVSFHFSNYFVGFLSEA TATLAGAGFTEEKDHLEWDL TVSKPLNVELPRSMVEVVTS WNLPMSYWLNNYVFKNALRL G |
| Tissue Specificity | Isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis. Isoform 2 and isoform 3 are expressed in substantia negra, spinal cord, heart and lung. |
| Function | Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. |
| Protein Name | Protein-Serine O-Palmitoleoyltransferase PorcupineProtein Mg61 |
| Database Links | Reactome: R-HSA-3238698Reactome: R-HSA-5340573 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein-Serine O-Palmitoleoyltransferase Porcupine antibodyAnti-Protein Mg61 antibodyAnti-PORCN antibodyAnti-MG61 antibodyAnti-PORC antibodyAnti-PPN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
