| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-POU domain, class 3, transcription factor 2 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POU3F2 |
| Gene ID: | 5454 |
| Uniprot ID: | PO3F2_HUMAN |
| Specificity: | PO3F2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes. |
| Protein Name | Pou Domain - Class 3 - Transcription Factor 2 Brain-Specific Homeobox/Pou Domain Protein 2 Brain-2 Brn-2 Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3 Octamer-Binding Protein 7 Oct-7 Octamer-Binding Transcription Factor 7 Otf-7 |
| Database Links | Reactome: R-HSA-9619665 Reactome: R-HSA-9824594 Reactome: R-HSA-9856649 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pou Domain - Class 3 - Transcription Factor 2 antibody Anti-Brain-Specific Homeobox/Pou Domain Protein 2 antibody Anti-Brain-2 antibody Anti-Brn-2 antibody Anti-Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3 antibody Anti-Octamer-Binding Protein 7 antibody Anti-Oct-7 antibody Anti-Octamer-Binding Transcription Factor 7 antibody Anti-Otf-7 antibody Anti-POU3F2 antibody Anti-BRN2 antibody Anti-OCT7 antibody Anti-OTF7 antibody |
Information sourced from Uniprot.org