| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PROC (43-460) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PROC |
| Gene ID: |
5624 |
| Uniprot ID: |
PROC_HUMAN |
| Immunogen Region: |
43-460 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 43-460 of human Coagulation Protein C (NP_000303.1). |
| Immunogen Sequence: |
ANSFLEELRHSSLERECIEE ICDFEEAKEIFQNVDDTLAF WSKHVDGDQCLVLPLEHPCA SLCCGHGTCIDGIGSFSCDC RSGWEGRFCQREVSFLNCSL DNGGCTHYCLEEVGWRRCSC APGYKLGDDLLQCHPAVKFP CGRPWKRMEKKRSHLKRDTE DQEDQVDPRLIDGKMTRRGD SPWQVVLLDSKKKLACGAVL IHPSWVLTAAHCMDESKKLL VRLGEYDLRRWEKWELDLD |
| Tissue Specificity | Plasma.synthesized in the liver. |
| Post Translational Modifications | The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium. N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide. |
| Function | Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. |
| Protein Name | Vitamin K-Dependent Protein CAnticoagulant Protein CAutoprothrombin IiaBlood Coagulation Factor Xiv Cleaved Into - Vitamin K-Dependent Protein C Light Chain - Vitamin K-Dependent Protein C Heavy Chain - Activation Peptide |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-159740Reactome: R-HSA-159763Reactome: R-HSA-159782Reactome: R-HSA-202733Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedGolgi ApparatusEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Vitamin K-Dependent Protein C antibodyAnti-Anticoagulant Protein C antibodyAnti-Autoprothrombin Iia antibodyAnti-Blood Coagulation Factor Xiv Cleaved Into - Vitamin K-Dependent Protein C Light Chain - Vitamin K-Dependent Protein C Heavy Chain - Activation Peptide antibodyAnti-PROC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
