Host: | Goat |
Applications: | Pep-ELISA/IHC |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Goat polyclonal antibody anti-proSAAS (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000. WB: Preliminary experiments in Human Brain and Pancreas lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). IHC: Paraffin embedded Human Pancrea |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | PCSK1N |
Gene ID: | 27344 |
Uniprot ID: | PCS1N_HUMAN |
Immunogen Region: | Internal |
Accession Number: | NP_037403.1 |
Immunogen Sequence: | EAGDETPDVDPE |
Post Translational Modifications | Proteolytically cleaved in the Golgi. O-glycosylated with a core 1 or possibly core 8 glycan. |
Function | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. Big LEN: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. PEN: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. |
Protein Name | Prosaas Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor Proprotein Convertase 1 Inhibitor Pro-Saas Cleaved Into - Kep - Big Saas B-Saas - Little Saas L-Saas N-Prosaas - Big Pen-Len B-Pen-Len Saas Ct(1-49 - Pen - Little Len L-Len - Big Len B-Len Saas Ct(25-40 |
Cellular Localisation | Secreted Golgi Apparatus Trans-Golgi Network A N-Terminal Processed Peptide Probably Big Saas Or Little Saas Is Accumulated In Cytoplasmic Protein Tau Deposits In Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 (Pick Disease) Alzheimer Disease And Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 (Guam Disease) |
Alternative Antibody Names | Anti-Prosaas antibody Anti-Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor antibody Anti-Proprotein Convertase 1 Inhibitor antibody Anti-Pro-Saas Cleaved Into - Kep - Big Saas antibody Anti-B-Saas - Little Saas antibody Anti-L-Saas antibody Anti-N-Prosaas - Big Pen-Len antibody Anti-B-Pen-Len antibody Anti-Saas Ct(1-49 - Pen - Little Len antibody Anti-L-Len - Big Len antibody Anti-B-Len antibody Anti-Saas Ct(25-40 antibody Anti-PCSK1N antibody |
Information sourced from Uniprot.org