| Short Description : | Rabbit polyclonal PTBP2 (1-280) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTBP2 |
| Gene ID: | 58155 |
| Uniprot ID: | PTBP2_HUMAN |
| Immunogen Region: | 1-280 |
| Immunogen Sequence: | MDGIVTEVAVGVKRGSDELL SGSVLSSPNSNMSSMVVTAN GNDSKKFKGEDKMDGAPSRV LHIRKLPGEVTETEVIALGL PFGKVTNILMLKGKNQAFLE LATEEAAITMVNYYSAVTPH LRNQPIYIQYSNHKELKTDN TLNQRAQAVLQAVTAVQTAN TPLSGTTVSESAVTPAQSPV LRIIIDNMYYPVTLDVLHQI FSKFGAVLKIITFTKNNQFQ ALLQYGDPVNAQQAKLALD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PTBP2 (NP_001287918.1). |
| Tissue Specificity | Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. |
| Function | RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5: Reduced affinity for RNA. |
| Protein Name | Polypyrimidine Tract-Binding Protein 2Neural Polypyrimidine Tract-Binding ProteinNeurally-Enriched Homolog Of PtbPtb-Like Protein |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polypyrimidine Tract-Binding Protein 2 antibodyAnti-Neural Polypyrimidine Tract-Binding Protein antibodyAnti-Neurally-Enriched Homolog Of Ptb antibodyAnti-Ptb-Like Protein antibodyAnti-PTBP2 antibodyAnti-NPTB antibodyAnti-PTB antibodyAnti-PTBLP antibody |
Information sourced from Uniprot.org
