Anti-PZP Antibody

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Product name Anti-PZP Antibody
Short Description Rabbit polyclonal against PZP
Description The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Pregnancy zone protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 620-740 of human PZP (NP_002855.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene Symbol PZP
Molecular Weight 163.863 kDa
Database Links HGNC:9750
OMIM:176420
Alternative Names Pregnancy zone protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism, This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases, When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase, The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced), Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Cellular Localization Secreted
Tissue Specificity Plasma, Prominent constituent of late-pregnancy sera
Swiss-Prot Key P20742
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