| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAPH1 (1-240) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAPH1 |
| Gene ID: |
65059 |
| Uniprot ID: |
RAPH1_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human RAPH1 (NP_998754.1). |
| Immunogen Sequence: |
MEQLSDEEIDHGAEEDSDKE DQDLDKMFGAWLGELDKLTQ SLDSDKPMEPVKRSPLRQET NMANFSYRFSIYNLNEALNQ GETVDLDALMADLCSIEQEL SSIGSGNSKRQITETKATQK LPVSRHTLKHGTLKGLSSSS NRIAKPSHASYSLDDVTAQL EQASLSMDEAAQQSVLEDTK PLVTNQHRRTASAGTVSDAE VHSISNSSHSSITSAASSMD SLDIDKVTRPQELDLTHQG |
| Tissue Specificity | Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. |
| Function | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Protein Name | Ras-Associated And Pleckstrin Homology Domains-Containing Protein 1Raph1Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 18 ProteinAmyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 9 ProteinLamellipodinProline-Rich Evh1 Ligand 2Prel-2Protein Rmo1 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumFilopodiumCytoplasmCytoskeletonRecruited To The MembraneVia The Ph DomainBy The PhosphoinositidePi(34)P2Colocalizes With Enah/Vasp At The Tips Of Lamellipodia And FilopodiaAlso Colocalizes With The PathogensVaccinia And Enteropathogenic EColi (Epec) At The Interface Between The Pathogen And Their Actin |
| Alternative Antibody Names | Anti-Ras-Associated And Pleckstrin Homology Domains-Containing Protein 1 antibodyAnti-Raph1 antibodyAnti-Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 18 Protein antibodyAnti-Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 9 Protein antibodyAnti-Lamellipodin antibodyAnti-Proline-Rich Evh1 Ligand 2 antibodyAnti-Prel-2 antibodyAnti-Protein Rmo1 antibodyAnti-RAPH1 antibodyAnti-ALS2CR18 antibodyAnti-ALS2CR9 antibodyAnti-KIAA1681 antibodyAnti-LPD antibodyAnti-PREL2 antibodyAnti-RMO1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
